Intralesional corticosteroid injections in the treatment of central giant cell lesions of the jaws: A meta-analytic study
نویسندگان
چکیده
OBJECTIVE The aim of this study was to evaluate the response of treatment of central giant cell lesion to intralesional corticosteroid injections. STUDY DESIGN Review of articles indexed in PubMed on the topic between the years 1988 and 2011, and development of a descriptive meta-analysis of the results. RESULTS Sample of 41 patients primarily treated with intralesional corticosteroid injections was obtained, with a male female ratio of 1:0.95, being 23 aggressive and 18 non-aggressive central giant cell lesions. Triamcinolone acetonide and triamcinolone hexacetonide were the drugs used, and 78.0% cases were considered as good result, 14.6% were considered as moderate response and 7.3% were considered as negative result to treatment. Considering the aggressiveness, 88.9% of non-aggressive lesions presented a good response to treatment, in aggressive central giant cell lesions, 69.6% presented a good response to intralesional corticosteroid injections. CONCLUSION In view of the results analyzed, intralesional corticosteroid injections could be considered as first treatment option for central giant cell lesion.
منابع مشابه
Central Giant Cell Granuloma of the Jaws: Correlation between Vascularity and Biologic Behavior
Introduction: Giant cell lesions of the bone comprise a group of jaw bone pathologies. Different pathogeneses such as reactive, vascular or neoplastic have been proposed for these lesions. In addition, differentiating between aggressive and nonaggressive central giant cell granuloma (CGCG) of the jaws based on histopathologic features is still impossible and due to different treatment protocols...
متن کاملEfficacy of EMLA cream in reduction of the pain of intralesional Corticosteroid injection in Alopecia Areata
Background: EMLA cream is a eutectic mixture of Lidocaine and Prilocaine used to induce local anesthesia for dermatological procedures. Objective: This study was designed to evaluate the efficacy of EMLA cream in reducing the pain of intralesional injection of steroid in patients with alopecia areata. Patients and Methods: This study was carried out on 27 alopecia areata patients. The injection...
متن کاملA 38- year demographic study of central and peripheral giant cell granulomas of the jaws
Objective: The purpose of this study was to retrospectively analyze the demographic characteristics of patients with central peripheral giant cell granulomas (CGCGs) / (PGCGs) an Iranian population. Methods: In this 38-year retrospective study, the data were obtained from records of 1019 patients with CGCG and PGCG of the jaws referred to the Department of Oral and Maxillofacial, Pathology, ...
متن کاملTreatment of central giant cell lesions using bisphosphonates with intralesional corticosteroid injections
Central giant cell lesions are benign intraosseous proliferative lesions that have considerable local aggressiveness. Nonsurgical treatment methods, such as intralesional corticosteroid injections, systemic calcitonin and interferon have been reported. Recently, bisphosphonates have been used to treat central giant cell lesions. A case of a 36-year-old male with a central giant cell lesion cros...
متن کاملIntralesional corticosteroid injection for central giant cell granuloma. A case report.
Central giant cell granuloma (CGCG) is a benign intraosseous lesion of the jaws that is found predominantly in children and young adults. Although benign, it may be locally aggressive, causing extensive bone destruction, tooth displacement and root resorption. The common therapy is aggressive curettage, peripheral ostectomy or resection, which may be associated with loss of teeth and, in younge...
متن کامل